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Activated through the antibiotic rifampicin and many plant metabolites, which include hyperforin, guggulipid, colupulone, and isoflavones. Response to precise ligands is species-precise. Activated by Normally occurring steroids, such as pregnenolone and progesterone. Binds to the response component from the promoters with the CYP3A4 and ABCB1/MDR1